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Our
Company
Sioux Biochemical has developed
specialized techniques and processes in large scale isolation
and purification of recombinant proteins from transgenic
grains. We also have the capability to extract and purify
non-recombinant products from plants. Our network
includes leading corporations and individuals in the
transgenic plant arena. Our team provides expertise in the
areas of:
- Protein Extraction, Purification,
Research and Development
- Process Development and Contract
Manufacturing
- Analytical Method Development
- Quality Technical
Support
Technology
Transfer
Sioux Biochemical will work with sponsor
companies to efficiently transfer and implement
their:
We will work with you during process
development, optimization and scale-up to provide a final
product that will best suit your needs. Sioux Biochemical will
also assist in risk and cost analysis of scaled-up
projects.
Facilities
Sioux Biochemical has recently
moved into a new state-of-the-art facility that contains
pilot and production facilities, quality control laboratories
and space for support personnel. Our facility also has
additional space for future expansion.
Manufacturing
Capabilities
Transgenic grain
extraction
Clarification
- Centrifugation (continuous flow basket,
decanter and disk
stack)
- Depth filtration (plate and
frame)
Chromatography
-
Amersham Bioprocess
system
- Ion
Exchange
- Affinity
Ultrafiltration /
Diafiltration
Lyophilization
Waste disposal
Analytical
Development & Support
Sioux Biochemical provides continuous
analytical support to process development and manufacturing
operations through our QC department. Assays are developed and
validated for in-process and final product analysis
which can include :
- Bioburden
- Purity
- Potency
- Identity
- Concentration
Regulatory
Support
Sioux Biochemical is committed to
following current Good Manufacturing Procedure guidelines.
Manufacturing can be performed under 21 CFR Parts 110 and 111
guidelines. | 
